Individual Prostate Cancer Risk Score
About
Stockholm3 is a blood test that combines protein markers, genetic markers, clinical data and a multivariate algorithm to create a more accurate way to screen for the risk of prostate cancer. STHLM3RS aims at accelerating introduction of Stockholm3 in Europe. Activities include clinical validation and development of a “technology agnostic” version that works on many platforms.
Origins
Currently, the most widely used blood test for prostate cancer is controversial because it can give false positives that lead men to have unneeded treatments or invasive tests that cause new health problems. Stockholm3 identifies twice as many aggressive prostate cancers and reduces the risk of conducting unnecessary prostate biopsies by 50%.
Team
STHLM3RS is led by Karolinska Institutet, a world-leading medical university, and Thermo Fisher Scientific, which provides both deep scientific knowledge and industrial and business development experience. Validation partners for STHLM3RS include clinicians at Erasmus University, University Medical Center Groningen, Friedrich-Alexander-Universität Erlangen and Taunton and Somerset NHS Foundation Trust.
The project
The EIT Health STHLM3RS Innovation Project aims at accelerating the introduction of Stockholm3 in Europe.
Key activities carried out during the project include:
- Clinical validation at five hospitals in Germany, Holland and the UK;
- Implementation of a technology agnostic solution;
- Setting up of a demonstration hospital at Capio S:t Göran Prostate Cancer Center in Stockholm, Sweden;
- Development of second-generation technology to analyse Stockholm3;
- Two spin-out companies:
- OncoAlgorithm: Develops/market tools that use genomics, proteomics and imaging in modern medicine.
- A23Lab: Sells a Research use Only (RUO) version of Stockholm3 as a Lab Developed test (LDT) in the Swedish/Nordic markets and acts as reference lab for further European roll-out.
Impact
Benefits of Stockholm3 include lower mortality from prostate cancer and fewer harmful misdiagnoses. Health economic calculations have proven the value of Stockholm3 for society. The STHLM3RS project has already achieved much in accelerating use of Stockholm3:
- Stockholm3 has been validated in several key markets;
- Stockholm3 has been implemented in clinical care as an LDT in Sweden, Norway and Finland;
- Stockholm3 has received strong interest from major lab chains in Europe and elsewhere.
Why this is an EIT Health project
This project drives a key goal of EIT Health by helping to accelerate a proven healthcare innovation toward the market. The project is particularly in keeping with the EIT Health Focus Area of “Care Pathways”, because it promises improved diagnoses of a potentially deadly condition that can better be treated if it is detected early.
Find out more about Stockholm3 and how the project has developed here.
Partners
CLC/InnoStars: Belgium-Netherlands
Partner classification: Education, Research, Hospital / University Hospital
Erasmus University Medical Center Rotterdam (Erasmus MC) is the largest university medical center in The Netherlands with around 16,500 employees, and a top referral hospital for a region of about five million inhabitants. A unique infrastructure bringing multidisciplinary research and healthcare together at one location allows Erasmus MC to excel in fundamental research, fast translation of findings into the clinic including first-in-man testing and clinical implementation, and epidemiological studies.
Technical university medical center: Technology is at the core of the new strategy. Erasmus MC focuses on the use of technology and data science to foster innovation in a variety of fields – from medical instruments and devices, minimally invasive surgery, imaging and image analysis, information technology and smart data technology to artificial intelligence, machine learning and biomedical technology.
Erasmus University Medical Centre Rotterdam
Erasmus University Medical Centre Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Key Activities in Research and Developement
Life Sciences, Social sciences / health economics, Clinical research
Key Activities in Social Innovation
Healthcare provision
Key Activities in Business Creation
Technology Transfer
Key Activities in Education
Medical faculties, Healthcare professional education/training
CLC/InnoStars: Germany
Partner classification: Education, Research, Hospital / University Hospital
Partner type: Core Partner
Founded in 1743, FAU has a rich history. It is a strong research university with an international perspective and one of the largest universities in Germany, with 39,780 students, 265 degree programmes and 4,000 academic staff. At Universitätsklinikum Erlangen (the university hospital), 7.400 employees promote health and cure disease. With up-to-date equipment and science-based diagnostic and therapeutic procedures, the 24 departments of the FAU, 25 clinical departments, 19 institutes, and 21 independent departments at Universitätsklinikum Erlangen comprehend every field of modern medicine.
Friedrich-Alexander-Universität Erlangen-Nürnberg
Friedrich-Alexander-Universität Erlangen-Nürnberg, Schloßplatz 4, 91054 Erlangen, Germany
Key Activities in Research and Developement
Biomedical engineering, Life Sciences, Social sciences / health economics
Key Activities in Social Innovation
Healthcare provision
Key Activities in Business Creation
Incubation, Technology Transfer
Key Activities in Education
Entrepreneurship training, Technical faculties, Medical faculties
CLC/InnoStars: Scandinavia
Partner classification: Education, Research
Partner type: Core Partner
Karolinska Institutet is one of the world's leading medical Universities. Our mission is to contribute to the improvement of human health through research and education. Our research covers the entire medical field, from basic molecular biological research, to clinical epidemiology and nursing science. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine. With our close relationship to the clinical world, a well-established infrastructure, a unique innovation system and financial stability, Karolinska Institutet has excellent prerequisites for sustaining high-quality research and education.
Key Activities in Corporate Innovation
Pharma, Med Tech, Diagnostics, Imaging, Nutrition
Key Activities in Social Innovation
Healthcare provision
Key Activities in Business Creation
Incubation, Technology Transfer, Business coaching, Testing & Validation
Key Activities in Education
Entrepreneurship training, Medical faculties, Healthcare professional education/training
CLC/InnoStars: Belgium-Netherlands
Partner classification: Education, Research
Partner type: Associate Partner
KU Leuven (together with University Hospitals Leuven) is a research-intensive, internationally oriented university that carries out excellence-driven research in health and care and is dedicated to build bridges between science, society and industry.
CLC/InnoStars: Scandinavia
Partner classification: Business
Partner type: Associate Partner
As the Immuno Diagnostic experts within Thermo Fisher Scientific, we develop, manufacture and market complete blood test systems to support clinical diagnosis and monitoring of allergy, asthma and autoimmune diseases.
Thermo Fisher Scientific
Thermo Fisher Scientific, Rapsgatan 7, 754 50 Uppsala, Sweden
Key Activities in Corporate Innovation
Pharma, Diagnostics
Key Activities in Social Innovation
Healthcare provision
Key Activities in Business Creation
Testing & Validation
Key Activities in Education
Medical faculties, Healthcare professional education/training
CLC/InnoStars: Belgium-Netherlands
Partner classification: Business, Education, Hospital / University Hospital
Partner type: Associate Partner
The UMCG is a large university medical center focused on patient care, education, research and innovation aiming at societal impact and economic growth. The UMCG focuses on healthy ageing in all priority areas: research, clinical care and education.
University Medical Center Groningen (UMCG)
University Medical Center Groningen (UMCG), Hanzeplein 1, 9713 GZ Groningen, Netherlands